| Student Organization (2019-2020) | Founded* | Current Head | Social |
| AIESEC in Pampanga | 2015 | Honelyn Zita Visperas |   |
| UP Association of Economics Students (AES) | 1982 |
Piela Nica G. Pineda
|
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| UP Babaylan | 2017 | Rozane Gul Mandi | |
| UP Business Management Society (BMS) | 1987 | Kevin Rae Taldo | |
| UP Psychology Society (PsychSoc) | 1984 | Niah Kyla P. Timbol | |
| Campus Crusade for Christ (CCC) | 1997 | Marie Venice Tongol | |
| UP Lakan | 1992 | Sydney Rose Santiago |  |
| UP Manga-Anime Associates (UP MANIA) | 2013 | Arman James P. Santos | |
| UP Musician’s Guild | 2015 | Sly Sioson | |
| Rotaract Club of UPDEPP | 2005 | Jacqueline Isip | |
| UP Samahang Mag-aaral na Nagkakaisa (SAMANA) | 1981 | Daphne Canlas | |
| Alpha Phi Omega Int’l Collegiate Fraternity & Sorority Omicron Chapter |
1960 | Charles Andrei D. Enriquez, Nicole A. Delfin | |
| Kappa Delta Sigma Sorority | 1988 |  |
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| Pi Sigma- Pi Sigma Delta Confraternity |
1981 (Pi Sigma Fraternity), 1982 (Pi Sigma Delta Sorority) |
Hazel Anne Gil | |
| STAND UP Clark | 2019 | Hannah Manuel | |
| Tau Gamma Phi Fraternity | 1986 | David Cabrera | |
| Tau Gamma Sigma Sorority | 1987 | Jelsea Bernardo | |