| Student Organization (2020-2021) | Founded* | Current Head | Social |
| AIESEC in Pampanga | 2015 | Honelyn Zita Visperas |   |
| UP Association of Economics Students (AES) | 1982 | Anna Patricia Lapid | |
| UP Babaylan | 2017 | Neojohn Robedillo | |
| UP Business Management Society (BMS) | 1987 | Alysia Mae Mayuyu | |
| UP Psychology Society (PsychSoc) | 1984 | Trisha Marzan | |
| Campus Crusade for Christ (CCC) | 1997 | Blessie Lampa | |
| UP Lakan | 1992 | Hanne Icasiano |  |
| UP Manga-Anime Associates (UP MANIA) | 2013 | Cara Roxas | |
| UP Musician’s Guild | 2015 | Ronnie Sangalang Jr. | |
| Rotaract Club of UPDEPP | 2005 | Jacqueline Isip | |
| UP Samahang Mag-aaral na Nagkakaisa (SAMANA) | 1981 | Aira De Goma | |
| Alpha Phi Omega Int’l Collegiate Fraternity & Sorority Omicron Chapter |
1960 | Charles Andrei D. Enriquez, Nicole A. Delfin | |
| Kappa Delta Sigma Sorority | 1988 | Anna Cenizal |  |
| Pi Sigma- Pi Sigma Delta Confraternity |
1981 (Pi Sigma Fraternity), 1982 (Pi Sigma Delta Sorority) |
Kyla Marie Genuino | |
| STAND UP Clark | 2019 | Hannah Manuel | |
| Tau Gamma Phi Fraternity | 1986 | Enzon Ambay | |
| Tau Gamma Sigma Sorority | 1987 | Gabriella Africa | |